Fri Jul 08 2022

25 articles - From Friday Jul 01 2022 to Friday Jul 08 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…

Pancreatology

Identification of high-risk germline variants for the development of pancreatic cancer: Common characteristics and potential guidance to screening guidelines.

Information from each study was analyzed to draw conclusions on these variants as well as their association with pancreatic cancer. Information from this review is intended to improve precision medicine and improve criteria for screening.

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Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Discordance between postprandial plasma glucose measurement and continuous glucose monitoring.

We discovered discordance between gold standard, fingerstick, and CGM in measuring plasma glucose concentrations after a meal. Consequently, emerging applications of CGM in healthy individuals, such as precision nutrition and diabetes onset prediction, may need to account for these discordances.Clinical Trial Registry

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Prunes preserve hip bone mineral density in a 12-month randomized controlled trial in postmenopausal women: the Prune Study.

A 50 g daily dose of prunes can prevent loss of total hip BMD in postmenopausal females after six months, which persisted for 12-months. Given that there was high compliance and retention at the 50 g dosage over 12 months, we propose that the 50 g dose represents a valuable non-pharmacological treatment strategy that can be used to preserve hip BMD in postmenopausal females and possibly reduce hip fracture risk. Clinical Trials Registry Number NCT02822378.

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Recreational physical activity before and during pregnancy and placental DNA methylation - an epigenome-wide association study.

Recreational PA in the year prior and during pregnancy was associated with placental DNAm. The associated CpG sites varied based on timing of PA. If replicated, the findings may inform the mechanisms underlying the impacts of PA on placenta health. Clinical trial registration

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Vitamin D status, genetic factors, and risk of cardiovascular disease among individuals with type 2 diabetes: a prospective study.

Higher serum 25(OH)D concentrations were significantly associated with lower risks of total CVD and IHD among patients with T2D, regardless of genetic susceptibility and genetic variants in VDR. Risk reductions tended to plateau at serum 25(OH)D levels around 50 nmol/L. These findings suggest that maintaining adequate vitamin D status and avoiding deficiency may help to prevent CVD complications among patients with T2D.

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Pancreas

Feasibility and Satisfaction of Using NET VITALS Self-assessment Tool Among Patients With Neuroendocrine Tumors.

NET VITALS is a feasible and acceptable self-assessment tool to potentially help patients improve communication about their NET diagnosis/treatment with their physician. Further studies will examine NET VITALS' generalizability and discuss its incorporation into clinical care.

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Hereditary Pancreatitis-25 Years of an Evolving Paradigm: Frank Brooks Memorial Lecture 2021.

Through the following 25 years, the ensuing discoveries fundamentally changed our understanding of pancreatitis pathogenesis, clarified the role of trypsinogen autoactivation in disease onset and progression, and set the stage for future therapeutic interventions. This Frank Brooks Memorial Lecture was delivered on November 4, 2021, at the 52nd Annual Meeting of the American Pancreatic Association, held in Miami Beach, Florida.

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Incidence of Pancreatic Intraepithelial Neoplasia in an Autopsy Series.

We conclude that the incidence of PanIN is higher than previously reported.

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Is There a Benefit From Islet Autotransplantation in Patients With Type 1 Diabetes Mellitus Undergoing Total Pancreatectomy?

In addition, total daily dose of insulin in 1 patient was able to be slightly reduced at 12 months post-TPIAT. We observed in vitro that residual a cells and ß cells in T1DM islets were able to secrete a small amount of glucagon and insulin, respectively.

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Pancreatology

Loss-of-function variant in chymotrypsin like elastase 3B (CELA3B) is associated with non-alcoholic chronic pancreatitis.

Our data indicate that CELA3B is a susceptibility gene for CP. In contrast to previous reports suggesting that increased CELA3B activity is associated with CP risk, the splice-site variant identified here is predicted to cause diminished CELA3B expression. How reduced CELA3B function predisposes to pancreatitis remains to be elucidated.

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Progression from biochemical leak to pancreatic fistula after distal pancreatectomy. Don't cry over spilt amylase.

Purulent fluid from surgical drains should be suspicious of BL upgrading. Frail patients undergoing longer interventions may represent key targets of mitigation strategies to minimize the magnitude of an incipient fistula and its increase in morbidity.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Liver Transpl

Caring for a child after a liver transplant: challenges beyond medical complexity.

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Letters&Replies

Letters to the editors and authors’ replies

Pancreatology

Distal pancreatectomy with and without routine Intraperitoneal drainage.

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Others

all remaining publications eg case reports, images of the month, etc…

Am J Clin Nutr

Bias attributable to the use of a composite outcome in evaluating a cocoa extract supplement.

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Non-dietary covariates of colorectal cancer risk in population cohorts.

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Reply to Ramírez PC and Diaz-Quijano FA (AJCN-D-22-00631).

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Reply to Tasci et al. and Lu et al.

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Residual confounding by antioxidants and multicollinearity in the polyphenol-colorectal cancer association.

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Pancreas

Concomitant Acute Pancreatitis and Coronavirus Disease 2019 Increases the Risk of Subsequent Endocrine Pancreatic Insufficiency Compared With Either Alone.

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Dramatic Response of a Pancreas Neuroendocrine Tumor Liver Metastasis to High-Dose Focal External Beam Radiotherapy: A Case Report.

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Is Elevated Pancreatic Enzyme Level in Coronavirus Disease 2019 Patients a Silent Bystander?

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Precision Oncology With Germline and Somatic Sequencing in Pancreatic Cancer: The Time Is Now.

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Serous Cystic Neoplasm With Typical Clinical Findings and Perineural Invasion.

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Serum n-3 Polyunsaturated Fatty Acids and C-Reactive Protein Concentrations Are Inversely Associated in Patients With Alcoholic Chronic Pancreatitis.

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Spontaneous Gallbladder Perforation in a Child With Anomalous Pancreaticobiliary Junction.

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